The role of β-hairpin conformation in ester hydrolysis peptide catalysts based on a TrpZip scaffold.
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ABSTRACT: To explore the role of peptide conformation on catalytic activity in the context of ester hydrolysis catalysts, pairs of sequences were designed that contained or lacked β-hairpin character. For the hydrolysis of para-nitrophenylacetate in aqueous media, we found small but consistent trends wherein His-containing sequences based on a TrpZip scaffold showed higher catalytic activity without β-hairpin character.
SUBMITTER: Liu X
PROVIDER: S-EPMC8285361 | biostudies-literature |
REPOSITORIES: biostudies-literature
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