The role of β-hairpin conformation in ester hydrolysis peptide catalysts based on a TrpZip scaffold.
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ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC8285361 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
The role of β-hairpin conformation in ester hydrolysis peptide catalysts based on a TrpZip scaffold.
Liu Xinyu X Waters Riley R Gilbert Hannah E HE Barroso Gage T GT Boyle Kelsey M KM Witus Leah S LS
RSC advances 20210706 38
To explore the role of peptide conformation on catalytic activity in the context of ester hydrolysis catalysts, pairs of sequences were designed that contained or lacked β-hairpin character. For the hydrolysis of <i>para</i>-nitrophenylacetate in aqueous media, we found small but consistent trends wherein His-containing sequences based on a <b>TrpZip</b> scaffold showed higher catalytic activity without β-hairpin character. ...[more]
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