Dataset Information

Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells.

ABSTRACT: Helicobacter pylori (H. pylori) infection is the most common cause of gastric cancer (GC). This microorganism is genetically diverse; GC is caused by several genetic deregulations in addition to environmental factors and bacterial virulence factors. lncRNAs (long noncoding RNAs) are significant biological macromolecules in GC, have specific functions in diseases, and could be therapeutic targets. Altered lncRNAs can lead to the abnormal expression of adjacent protein-coding genes, which may be important in cancer development. Their mechanisms have not been well understood, so we are going to investigate the risk of GC in a population with both high lncRNA and H. pylori infection.

SUBMITTER: Yousefi L

PROVIDER: S-EPMC8286195 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells.

Yousefi Leila L Osquee Hamid Owaysee HO Ghotaslou Reza R Rezaee Mohammad Ahangarzadeh MA Pirzadeh Tahereh T Sadeghi Javid J Hemmati Fatemeh F Yousefi Bahman B Moaddab Seyyed Yaghoub SY Yousefi Mehdi M Shirmohammadi Masoud M Somi Mohammad Hossein MH Ganbarov Khudaverdi K Kafil Hossein Samadi HS

BioMed research international 20210709

Helicobacter pylori (H. pylori) infection is the most common cause of gastric cancer (GC). This microorganism is genetically diverse; GC is caused by several genetic deregulations in addition to environmental factors and bacterial virulence factors. lncRNAs (long noncoding RNAs) are significant biological macromolecules in GC, have specific functions in diseases, and could be therapeutic targets. Altered lncRNAs can lead to the abnormal expression of adjacent protein-coding genes, ...[more]

PMID: 34337048

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Project description:Helicobacter pylori (H. pylori) is well-known to be involved in gastric carcinogenesis, associated with deregulation of cell proliferation and epigenetic changes in cancer-related genes. H. pylori infection is largely acquired during childhood, persisting long-term in about half of infected individuals, a subset of whom will go on to develop peptic ulcer disease and eventually gastric cancer, however, the sequence of events leading to disease is not completely understood. Knowledge on carcinogenesis and gastric damage-related biomarkers is abundant in adult populations, but scarce in children. We performed an extensive literature review focusing on gastric cancer related biomarkers identified in adult populations, which have been detected in children infected with H. pylori. Biomarkers were related to expression levels (RNA or protein) and/or methylation levels (DNA) in gastric tissue or blood of infected children as compared to non-infected controls. In this review, we identified 37 biomarkers of which 24 are over expressed, three are under expressed, and ten genes are significantly hypermethylated in H. pylori-infected children compared to healthy controls in at least 1 study. Only four of these biomarkers (pepsinogen I, pepsinogen II, gastrin, and SLC5A8) have been studied in asymptomatically infected children. Importantly, 13 of these biomarkers (β-catenin, C-MYC, GATA-4, DAPK1, CXCL13, DC-SIGN, TIMP3, EGFR, GRIN2B, PIM2, SLC5A8, CDH1, and VCAM-1.) are consistently deregulated in infected children and in adults with gastric cancer. Future studies should be designed to determine the clinical significance of these changes in infection-associated biomarkers in children and their persistence over time. The effect of eradication therapy over these biomarkers in children if proven significant, could lead to modifications in treatment guidelines for younger populations, and eventually promote the development of preventive strategies, such as vaccination, in the near future.

Dataset Information

Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells.

Publications

Dysregulation of lncRNA in <i>Helicobacter pylori</i>-Infected Gastric Cancer Cells.

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