Allopurinol hepatotoxicity is associated with human leukocyte antigen Class I alleles.

ABSTRACT:

Background/aims

Allopurinol can cause HLA class I-associated life-threatening severe skin reactions. However, HLA risk and association with clinical features in allopurinol hepatotoxicity are unknown.

Methods

Eleven of 17 patients with suspected allopurinol hepatotoxicity enrolled into the Drug-Induced Liver Injury Network were adjudicated as definite, highly likely, or probable. High-resolution HLA sequencing was undertaken in cases and compared with population and other DILI controls.

Result

Median age was 60 years, 54% were male, and 63% African- American, 27% Caucasian, and 9% Hispanic. Patients presented at a median of 52 days after starting allopurinol, all were hospitalized and six were jaundiced. The median peak ALT, alkaline phosphatase, and total bilirubin w

SUBMITTER: Fontana RJ 

PROVIDER: S-EPMC8286350 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature