Plumbagin can potently enhance the activity of xanthine oxidase: in vitro, in vivo and in silico studies.

ABSTRACT:

Background

Abnormally elevated xanthine oxidase (XO) activity has been verified to cause various pathological processes, such as gout, oxidative stress injury and metabolic syndrome. Thus, XO activators may exhibit above potential toxicological properties. Plumbagin (PLB) is an important active compound in traditional Chinese medicine (TCM), while its obvious toxic effects have been reported, including diarrhea, skin rashes and hepatic toxicity. However, the potential toxicity associated with enhancement of XO activity has not been fully illuminated so far.

Methods

The present study investigated the effect of PLB on XO activity by culturing mouse liver S9 (MLS9), human liver S9 (HLS9), XO monoenzyme system with PLB and xanthine. Then, the molecular docking and biolayer inter

SUBMITTER: Yue L 

PROVIDER: S-EPMC8286619 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature