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Infer HIV transmission dynamics from gene sequences among young men who have sex with men in China.


ABSTRACT: To investigate the transmission dynamics and temporal and spatial migration characteristics of HIV spread among men who have sex with men (MSM) in China, a total of 1012 HIV-1 partial pol sequences, including five subtypes, were studied. Bayesian analysis were applied for each subtype to infer its dynamic characters including the effective reproductive number (R e ) and migration process. The mean curve of each R e was almost always greater than 1 (even the 95% highest posterior density (HPD) lower value) along with time, which supports the necessity for a comprehensive study about risk behaviors among young MSM group in China. We also should reappraise the free treatment strategy, especially the therapeutic effect during the free treatment policy.

SUBMITTER: Jin X 

PROVIDER: S-EPMC8286960 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Infer HIV transmission dynamics from gene sequences among young men who have sex with men in China.

Jin Xin X   Cheng Jinjin J   Lou Jie J  

Infectious Disease Modelling 20210710


To investigate the transmission dynamics and temporal and spatial migration characteristics of HIV spread among men who have sex with men (MSM) in China, a total of 1012 HIV-1 partial pol sequences, including five subtypes, were studied. Bayesian analysis were applied for each subtype to infer its dynamic characters including the effective reproductive number (<i>R</i> <sub><i>e</i></sub> ) and migration process. The mean curve of each <i>R</i> <sub><i>e</i></sub> was almost always greater than  ...[more]

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