Herpesviruses Serology Distinguishes Different Subgroups of Patients From the United Kingdom Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Biobank.

ABSTRACT: The evidence of an association between Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and chronic herpesviruses infections remains inconclusive. Two reasons for the lack of consistent evidence are the large heterogeneity of the patients' population with different disease triggers and the use of arbitrary cutoffs for defining seropositivity. In this work we re-analyzed previously published serological data related to 7 herpesvirus antigens. Patients with ME/CFS were subdivided into four subgroups related to the disease triggers: S₀-42 patients who did not know their disease trigger; S₁-43 patients who reported a non-infection trigger; S₂-93 patients who reported an infection trigger, but that infection was not confirmed by a lab test; and S

SUBMITTER: Domingues TD 

PROVIDER: S-EPMC8287507 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature