Relationship between regional gray matter volumes and dopamine D₂ receptor and transporter in living human brains.

ABSTRACT: Although striatal dopamine neurotransmission is believed to be functionally linked to the formation of the corticostriatal network, there has been little evidence for this regulatory process in the human brain and its disruptions in neuropsychiatric disorders. Here, we aimed to investigate associations of striatal dopamine transporter (DAT) and D₂ receptor availabilities with gray matter (GM) volumes in healthy humans. Positron emission tomography images of D₂ receptor (n = 34) and DAT (n = 17) captured with the specific radioligands [¹¹ C]raclopride and [¹⁸ F]FE-PE2I, respectively, were acquired along with T1-weighted magnetic resonance imaging data in our previous studies, and were re-analyzed in this work. We quantified the binding potentials

SUBMITTER: Kurose S 

PROVIDER: S-EPMC8288088 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature