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Global transcriptomic changes occur in uterine fluid-derived extracellular vesicles during the endometrial window for embryo implantation.


ABSTRACT:

SUBMITTER: Giacomini E 

PROVIDER: S-EPMC8289330 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Global transcriptomic changes occur in uterine fluid-derived extracellular vesicles during the endometrial window for embryo implantation.

Giacomini E E   Scotti G M GM   Vanni V S VS   Lazarevic D D   Makieva S S   Privitera L L   Signorelli S S   Cantone L L   Bollati V V   Murdica V V   Tonon G G   Papaleo E E   Candiani M M   Viganò P P  

Human reproduction (Oxford, England) 20210701 8


<h4>Study question</h4>Are uterine fluid-derived extracellular vesicles (UF-EVs) a 'liquid biopsy' reservoir of biomarkers for real-time monitoring of endometrial status?<h4>Summary answer</h4>The transcriptomic cargo of UF-EVs reflects the RNA profile of the endometrial tissue as well as changes between the non-receptive and the receptive phase, possibly supporting its use for a novel endometrial receptivity test.<h4>What is known already</h4>EVs have been previously isolated from uterine fluid  ...[more]

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