FER Regulated by miR-206 Promotes Hepatocellular Carcinoma Progression via NF-κB Signaling.

ABSTRACT:

Objectives

Feline sarcoma-related protein (FER) is known to play a critical regulatory role in several carcinomas. However, the exact biological function of FER in hepatocellular carcinoma (HCC) still needs to be investigated. The primary objective of this research was to investigate the unknown function and molecular mechanisms of FER in HCC.

Materials and methods

The expression level of FER in HCC tissue samples and cells was examined by RT-qPCR, immunohistochemistry and western blot. Cellular and animal experiments were used to explore the effect of FER on the proliferative and metastatic capacities of HCC cells. The crosstalk between FER and NF-κB signaling was explored by western blot. The upstream factors that regulate FER were evaluated through dual-luciferase experim

SUBMITTER: Ding W 

PROVIDER: S-EPMC8289706 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature