Dynamics of inhaled corticosteroid use are associated with asthma attacks.

ABSTRACT: Inhaled corticosteroids (ICS) suppress eosinophilic airway inflammation in asthma, but patients may not adhere to prescribed use. Mean adherence-averaging total doses taken over prescribed-fails to capture many aspects of adherence. Patients with difficult-to-treat asthma underwent electronic monitoring of ICS, with data collected over 50 days. These were used to calculate entropy (H) a measure of irregular inhaler use over this period, defined in terms of transitional probabilities between different levels of adherence, further partitioned into increasing (H_inc) or decreasing (H_dec) adherence. Mean adherence, time between actuations (Gap_max), and cumulative time- and dose-based variability (area-under-the-curve) were measured. Associations between adherenc

SUBMITTER: Lee J 

PROVIDER: S-EPMC8289909 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature