Comparative efficacy and safety of late surfactant preparations: a retrospective study.
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ABSTRACT: Objective
Characterize the use, efficacy, and safety of poractant alfa and calfactant surfactants compared to beractant in preterm infants receiving late surfactant.Study design
We included infants <37 weeks gestational age (GA) discharged from Pediatrix Medical Group-managed neonatal intensive care units (1997-2017). Efficacy and safety outcomes of interest were analyzed.Results
Of 184,770 infants administered surfactant at any time, 7846 (4.23%) received late surfactant at a median (25th, 75th percentile) PNA of 8 days (3, 22); specifically, 2976 received poractant alfa (38%), 2890 beractant (37%), and 1936 calfactant (25%). We identified no significant differences in composite efficacy or safety outcomes between surfactants in the primary analysis, but 33-36 week GA infants administered poractant alfa had significantly greater odds of developing a safety event.Conclusions
Compared to beractant, there is no evidence of overall superior efficacy or safety of poractant alfa.
SUBMITTER: Lane MD
PROVIDER: S-EPMC8290378 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Comparative efficacy and safety of late surfactant preparations: a retrospective study.
Lane Morgan D MD Kishnani Sujata S Udemadu Obianuju O Danquah Samuel Eshun SE Treadway Robert M RM Langman Aaliyah A Balevic Stephen S Jackson Wesley M WM Laughon Matthew M Hornik Christoph P CP Greenberg Rachel G RG Clark Reese H RH Zimmerman Kanecia O KO
Journal of perinatology : official journal of the California Perinatal Association 20210720 11
<h4>Objective</h4>Characterize the use, efficacy, and safety of poractant alfa and calfactant surfactants compared to beractant in preterm infants receiving late surfactant.<h4>Study design</h4>We included infants <37 weeks gestational age (GA) discharged from Pediatrix Medical Group-managed neonatal intensive care units (1997-2017). Efficacy and safety outcomes of interest were analyzed.<h4>Results</h4>Of 184,770 infants administered surfactant at any time, 7846 (4.23%) received late surfactant ...[more]
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