Preoperative Radiomics Analysis of 1p/19q Status in WHO Grade II Gliomas.

ABSTRACT:

Purpose

The present study aimed to preoperatively predict the status of 1p/19q based on radiomics analysis in patients with World Health Organization (WHO) grade II gliomas.

Methods

This retrospective study enrolled 157 patients with WHO grade II gliomas (76 patients with astrocytomas with mutant IDH, 16 patients with astrocytomas with wild-type IDH, and 65 patients with oligodendrogliomas with mutant IDH and 1p/19q codeletion). Radiomic features were extracted from magnetic resonance images, including T1-weighted, T2-weighted, and contrast T1-weighted images. Elastic net and support vector machines with radial basis function kernel were applied in nested 10-fold cross-validation loops to predict the 1p/19q status. Receiver operating characteristic analysis and precision-rec

SUBMITTER: Fan Z 

PROVIDER: S-EPMC8290517 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature