Assessing the external validity of the VALIDATE-SWEDEHEART trial.

ABSTRACT:

Aims

The VALIDATE-SWEDEHEART trial was a registry-based randomized trial comparing bivalirudin and heparin in patients with acute myocardial infarction undergoing percutaneous coronary intervention. It showed no differences in mortality at 30 or 180 days. This study examines how well the trial population results may generalize to the population of all screened patients with fulfilled inclusion criteria in regard to mortality at 30 and 180 days.

Methods

The standardized difference in the mean propensity score for trial inclusion between trial population and the screened not-enrolled with fulfilled inclusion criteria was calculated as a metric of similarity. Propensity scores were then used in an inverse-probability weighted Cox regression analysis using the trial population o

SUBMITTER: Rylance RT 

PROVIDER: S-EPMC8290983 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature