Defining the Qualities of High-Quality Palladium on Carbon Catalysts for Hydrogenolysis.
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ABSTRACT: Palladium-catalyzed hydrogenolysis is often the final step in challenging natural product total syntheses and a key step in industrial processes producing fine chemicals. Here, we demonstrate that there is wide variability in the efficiency of commercial sources of palladium on carbon (Pd/C) resulting in significant differences in selectivity, reaction times, and yields. We identified the physicochemical properties of efficient catalysts for hydrogenolysis: (1) small Pd/PdO particle size (2) homogeneous distribution of Pd/PdO on the carbon support, and (3) palladium oxidation state are good predictors of catalytic efficiency. Now chemists can identify and predict a catalyst's efficiency prior to the use of valuable synthetic material and time.
SUBMITTER: Crawford CJ
PROVIDER: S-EPMC8291771 | biostudies-literature |
REPOSITORIES: biostudies-literature
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