Dataset Information

In Situ Viscoelasticity Behavior of Cellulose-Chitin Composite Hydrogels during Ultrasound Irradiation.

ABSTRACT: Composite hydrogels with different cellulose and chitin loading were prepared, and their in-situ viscoelastic properties were estimated under cyclic exposure of 43 kHz and 30 W ultrasound (US) using a sono-deviced rheometer. US transmitted into the hydrogel caused it to soften within about 10 sec, thus causing a decline in the storage modulus (G') and loss modulus (G''). However, when the US was stopped, the G' and G'' returned to their initial values. Here, G' dropped gradually in response to the US irradiation, especially in the first cycle. After the second and third cycles, the decline was much quicker, within a few seconds. When the chitin component in the hydrogel was increased, the drop was significant. FTIR analysis of the hydrogels suggested that the peaks of -OH stretching and amide I vibration near 1655 cm^-1 shifted towards lower wave numbers after the third cycle, meaning that the US influenced the hydrogen bonding interaction of the chitin amide group. This repetitive effect contributed to the breakage of hydrogen bonds and increased the interactions of the acetylamine group in chitin and in the -OH groups. Eventually, the matrix turned into a more stabilized hydrogel.

SUBMITTER: Iresha H

PROVIDER: S-EPMC8293256 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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In Situ Viscoelasticity Behavior of Cellulose-Chitin Composite Hydrogels during Ultrasound Irradiation.

Iresha Harshani H Kobayashi Takaomi T

Gels (Basel, Switzerland) 20210630 3

Composite hydrogels with different cellulose and chitin loading were prepared, and their in-situ viscoelastic properties were estimated under cyclic exposure of 43 kHz and 30 W ultrasound (US) using a sono-deviced rheometer. US transmitted into the hydrogel caused it to soften within about 10 sec, thus causing a decline in the storage modulus (G') and loss modulus (G''). However, when the US was stopped, the G' and G'' returned to their initial values. Here, G' dropped gradually in response to t ...[more]

PMID: 34209349

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Project description:Dynamic covalent crosslinked (DCC) hydrogels represent a significant advance in biomaterials for regenerative medicine and mechanobiology. These gels typically offer viscoelasticity and self-healing properties that more closely mimic in vivo tissue mechanics than traditional, predominantly elastic, covalent crosslinked hydrogels. Despite their promise, the effects of varying crosslinker architecture - side chain versus telechelic crosslinks - on the viscoelastic properties of DCC hydrogels have not been thoroughly investigated. This study introduces hydrazone-based alginate hydrogels and examines how side-chain and telechelic crosslinker architectures impact hydrogel viscoelasticity and stiffness. In hydrogels with side-chain crosslinking (SCX), higher polymer concentrations enhance stiffness and decelerates stress relaxation, while an off-stoichiometric hydrazine-to-aldehyde ratio leads to reduced stiffness and shorter relaxation time. In hydrogels with telechelic crosslinking, maximal stiffness and slowest stress relaxation occurs at intermediate crosslinker concentrations for both linear and star crosslinkers, with higher crosslinker valency further increasing stiffness and relaxation time. Our result suggested different ranges of stiffness and stress relaxation are accessible with the different crosslinker architectures, with SCX hydrogels leading to slower stress relaxation relative to the other architectures, and hydrogels with star crosslinking (SX) providing increased stiffness and slower stress relaxation relative to hydrogels with linear crosslinking (LX). The mechanical properties of SX hydrogels are more robust to changes induced by competing chemical reactions compared to LX hydrogels. Our research underscores the pivotal role of crosslinker architecture in defining hydrogel stiffness and viscoelasticity, providing crucial insights for the design of DCC hydrogels with tailored mechanical properties for specific biomedical applications.

Dataset Information

In Situ Viscoelasticity Behavior of Cellulose-Chitin Composite Hydrogels during Ultrasound Irradiation.

Publications

In Situ Viscoelasticity Behavior of Cellulose-Chitin Composite Hydrogels during Ultrasound Irradiation.

Similar Datasets

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