Dissociative symptoms with intravenous ketamine in treatment-resistant depression exploratory observational study.

ABSTRACT:

Abstract

There is evidence for ketamine use in treatment-resistant depression (TRD). Several safety and tolerability concerns arise regarding adverse drug reactions and specific subpopulations. This paper aims to investigate the relationship between dissociative and psychometric measures in course of intravenous ketamine treatment in TRD inpatients with major depressive disorder and bipolar disorder.This study result represents safety data in a population of 49 inpatients with major depressive disorder and bipolar disorder subjects receiving eight 0.5 mg/kg of ketamine intravenous infusions, with a duration of 40 min each, as an add-on treatment to standard-of-care pharmacotherapy, registered in the naturalistic observational protocol of the tertiary reference unit for mood disorde

SUBMITTER: Wlodarczyk A 

PROVIDER: S-EPMC8294865 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature