ECCO₂R in 12 COVID-19 ARDS Patients With Extremely Low Compliance and Refractory Hypercapnia.

ABSTRACT: Purpose: A phenotype of COVID-19 ARDS patients with extremely low compliance and refractory hypercapnia was found in our ICU. In the context of limited number of ECMO machines, feasibility of a low-flow extracorporeal carbon dioxide removal (ECCO₂R) based on the renal replacement therapy (RRT) platform in these patients was assessed. Methods: Single-center, prospective study. Refractory hypercapnia patients with COVID-19-associated ARDS were included and divided into the adjusted group and unadjusted group according to the level of PaCO₂ after the application of the ECCO₂R system. Ventilation parameters [tidal volume (VT), respiratory rate, and PEEP], platform pressure (Pplat) and driving pressure (DP), respiratory system compliance, arterial

SUBMITTER: Ding X 

PROVIDER: S-EPMC8295461 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature