Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC8298759 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Li Xiang X Tang Xiaonan X Wang Yufei Y Chai Changwei C Zhao Zhehui Z Zhang Haijing H Peng Ying Y Wu Lianqiu L
Frontiers in pharmacology 20210709
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that affects 1% of the population. CS-semi5 is a semisynthetic chondroitin sulfate. In this study, CS-semi5 was shown to have positive effects on a model of collagen-induced arthritis (CIA). CS-semi5 treatment had obvious effects on weight loss and paw swelling in CIA mice. Post-treatment analysis revealed that CS-semi5 alleviated three main pathologies (i.e., synovial inflammation, cartilage erosion and bone loss) in a dose-dep ...[more]