Ontology highlight
ABSTRACT:
SUBMITTER: Kim SH
PROVIDER: S-EPMC8300234 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Kim Soo-Hyeon SH Seung Byung-Joon BJ Cho Seung-Hee SH Lim Ha-Young HY Bae Min-Kyung MK Sur Jung-Hyang JH
Animals : an open access journal from MDPI 20210712 7
The PI3K/Akt/PTEN axis is one of the most important signaling pathways in tumorigenesis. Recently, mutation of PIK3CA has been highlighted due to the similarities of mutational hotspots in both dogs and humans. PIK3CA H1047R (c.3140A > G) has been discovered as the most common mutational hot spot in canine mammary tumor in recent studies, while the feature of PIK3CA-mutated canine mammary tumor is obscure.<h4>Methods</h4>A total of 83 mammary samples classified as normal (<i>n</i> = 13), adenoma ...[more]