Unknown

Dataset Information

0

A Novel Recombinant Fcγ Receptor-Targeted Survivin Combines with Chemotherapy for Efficient Cancer Treatment.


ABSTRACT: Formyl peptide receptor-like 1 inhibitor (FLIPr), an Fcγ receptor (FcγR) antagonist, can be used as a carrier to guide antigen-FLIPr fusion protein to FcγR then enhances antigen-specific immune responses. Survivin, a tumor-associated antigen, is over-expressed in various types of human cancer. In this study, we demonstrate that recombinant survivin-FLIPr fusion protein (rSur-FLIPr) binds to FcγRs, and efficient uptake by dendritic cells in vivo. In addition, rSur-FLIPr alone stimulates survivin-specific immune responses, which effectively suppresses the tumor growth. The antitumor immunities are through TAP-mediated and CD8-dependent pathways. Furthermore, preexisting anti-FLIPr antibody does not abolish antitumor responses induced by rSur-FLIPr immunization. These results suggest that FLIPr is an effective antigen delivery vector and can be repeatedly used. Combination of chemotherapy with rSur-FLIPr treatment reveals a great benefit to tumor-bearing mice. Altogether, these findings suggest that rSur-FLIPr is a potential candidate for efficient cancer therapy.

SUBMITTER: Wu CC 

PROVIDER: S-EPMC8301409 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5354496 | biostudies-literature
2024-05-21 | PXD043966 | Pride
| S-EPMC5932405 | biostudies-literature
| S-EPMC3958055 | biostudies-literature
| S-EPMC8739678 | biostudies-literature
| S-EPMC6957139 | biostudies-literature
| S-EPMC4524353 | biostudies-literature
| S-EPMC6894221 | biostudies-literature
| S-EPMC3192435 | biostudies-literature
| S-EPMC6804482 | biostudies-other