Topographical reorganization of brain functional connectivity during an early period of epileptogenesis.

ABSTRACT:

Objective

The current study aims to investigate functional brain network representations during the early period of epileptogenesis.

Methods

Eighteen rats with the intrahippocampal kainate model of mesial temporal lobe epilepsy were used for this experiment. Functional magnetic resonance imaging (fMRI) measurements were made 1 week after status epilepticus, followed by 2-4-month electrophysiological and video monitoring. Animals were identified as having (1) developed epilepsy (E+, n = 9) or (2) not developed epilepsy (E-, n = 6). Nine additional animals served as controls. Graph theory analysis was performed on the fMRI data to quantify the functional brain networks in all animals prior to the development of epilepsy. Spectrum clustering with the network features was perfor

SUBMITTER: Li L 

PROVIDER: S-EPMC8302261 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature