Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation.
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ABSTRACT:
SUBMITTER: Iorio C
PROVIDER: S-EPMC8302759 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation.
Iorio Caterina C Rourke Jillian L JL Wells Lisa L Sakamaki Jun-Ichi JI Moon Emily E Hu Queenie Q Kin Tatsuya T Screaton Robert A RA
Communications biology 20210723 1
Loss of pancreatic β cells is the hallmark of type 1 diabetes, for which provision of insulin is the standard of care. While regenerative and stem cell therapies hold the promise of generating single-source or host-matched tissue to obviate immune-mediated complications, these will still require surgical intervention and immunosuppression. Here we report the development of a high-throughput RNAi screening approach to identify upstream pathways that regulate adult human β cell quiescence and demo ...[more]
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