In Silico Analysis of the Longevity and Timeline of Individual Germinal Center Reactions in a Primary Immune Response.

ABSTRACT: Germinal centers (GCs) are transient structures in the secondary lymphoid organs, where B cells undergo affinity maturation to produce high affinity memory and plasma cells. The lifetime of GC responses is a critical factor limiting the extent of affinity maturation and efficiency of antibody responses. While the average lifetime of overall GC reactions in a lymphoid organ is determined experimentally, the lifetime of individual GCs has not been monitored due to technical difficulties in longitudinal analysis. In silico analysis of the contraction phase of GC responses towards primary immunization with sheep red blood cells suggested that if individual GCs had similar lifetimes, the data would be consistent only when new GCs were formed until a very late phase after immunization. Alternati

SUBMITTER: Arulraj T 

PROVIDER: S-EPMC8306527 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature