GSI Treatment Preserves Protein Synthesis in C2C12 Myotubes.
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ABSTRACT:
SUBMITTER: Huot JR
PROVIDER: S-EPMC8307118 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
GSI Treatment Preserves Protein Synthesis in C2C12 Myotubes.
Huot Joshua R JR Thompson Brian B McMullen Charlotte C Marino Joseph S JS Arthur Susan T ST
Cells 20210715 7
It has been demonstrated that inhibiting Notch signaling through γ-secretase inhibitor (GSI) treatment increases myogenesis, AKT/mTOR signaling, and muscle protein synthesis (MPS) in C2C12 myotubes. The purpose of this study was to determine if GSI-mediated effects on myogenesis and MPS are dependent on AKT/mTOR signaling. C2C12 cells were assessed for indices of myotube formation, anabolic signaling, and MPS following GSI treatment in combination with rapamycin and API-1, inhibitors of mTOR and ...[more]
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