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Community-based monitoring to facilitate water management by local institutions in Costa Rica.

ABSTRACT: Water scarcity is a global problem that can be compounded by inefficient water management, including underinvestment in infrastructure, underpricing of water use, and underenforcement of user rules. Here, we explore whether these inefficiencies can be reduced in rural Costa Rica via an externally driven community monitoring program (i.e., a program initiated by an outside organization and run by citizens). The monitoring program aimed to reduce groundwater extraction from aquifers, as well as to improve water quality and user satisfaction, by supplying additional information about field conditions and additional scrutiny of user and management authority activities and by fostering citizen engagement in water management. Using a specially designed smartphone application (app) and WhatsApp, monitors could report weekly on the conditions of the water system, including service disruptions, water quality, leaks, and source contamination. The app automatically compiled the individual reports into a summary report, which was then made available to the community water management committees and water users. The program was randomly implemented in 80 of 161 communities that expressed an interest in participating. One year after the program started, we detect modest, albeit imprecisely estimated, effects of the program in the predicted directions: less groundwater extracted, better water quality, and more satisfied users. Although the estimated effects are imprecise, the monitoring program appears to be equally or more cost effective for reducing groundwater extraction than another program in the same region that encouraged households to adopt water-efficient technologies.

SUBMITTER: Bernedo Del Carpio M

PROVIDER: S-EPMC8307738 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Rationale: MicroRNAs have emerged as crucial post-transcriptional and network regulators in inflammatory diseases, including asthma. We hypothesized that peripheral blood miRNA would be associated with airflow obstruction in children with asthma, and that some of these effects would also be observable in adults with COPD. Methods: We analyzed small RNA-Seq data from 365 peripheral blood samples from the Genetics of Asthma in Costa Rica Study (GACRS). GACRS comprised children from the Central Valley of Costa Rica age 6-14 years with physician-diagnosed asthma and ≥2 respiratory symptoms or asthma attacks in the prior year. FEV1/FVC percent-predicted was dichotomized at 100%, splitting the cohort into those with and without evidence of airflow obstruction and used as our primary outcome. Differentially expressed (DE) miRs were identified using the DESeq2 package in R with a 10% FDR and adjustment for age, gender, and inhaled corticosteroid (ICS) use. We attempted to replicate the top airflow obstruction-associated microRNAs from the GACRS study in the COPDGene study, in which blood microRNA data were available in 439 current and former smoking adults with and without airflow obstruction (defined as raw FEV1/FVC < 0.7). Results: After QC, we had 361 samples and 649 miRs for DE analysis. Of the 361 samples, 220 and 141 were from subjects without and with airflow obstruction, respectively. We found 1 upregulated (let-7e-5p p=0.0004) and 2 downregulated (miR-342-3p p=0.0002; miR-671-5p p=0.0001) miRs in subjects with airflow obstruction compared to those without airflow obstruction. These three miRNAs were then tested for association with airflow obstruction in the COPDGene study, in which let-7e-5p was upregulated (p = 0.064) and miR-342-3p (p =0.085) was downregulated in participants with FEV1/FVC < 0.7 (n=196) compared to those with FEV1/FVC > 0.7 (n=243). Differentially expressed miR’s target genes were enriched for PI3K-Akt, Hippo, WNT, MAPK, and focal adhesion signaling pathways. We also separately considered the targets of only the two miRNAs that were also associated with FEV1/FVC in the adult current and former smokers, where PI3K-Akt, MAPK and Hippo signaling pathways were among the top five most enriched pathways. Conclusion: Three DE miRs were linked to airflow obstruction in children with asthma. Two miRs were associated with FEV1/FVC in current and former smoking adults. These miRs were involved in asthma and COPD-related pathways: PI3K-Akt, Hippo, MAPK, and focal adhesion signaling pathways. Together these findings provide important evidence that these two disorders may share genetic regulatory systems that contribute to airflow obstruction.

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Community-based monitoring to facilitate water management by local institutions in Costa Rica.

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