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A Novel Approach to the Facile Growth and Organization of Photothermal Prussian Blue Nanocrystals on Different Surfaces.

ABSTRACT: We report here a novel "one-pot" approach for the controlled growth and organization of Prussian blue nanostructures on three different surfaces: pure Au⁰, cysteamine-functionalized Au⁰, and SiO₂-supported lipid bilayers with different natures of lipids. We demonstrate that fine control over the size, morphology, and the degree and homogeneity of the surface coverage by Prussian Blue (PB) nanostructures may be achieved by manipulating different parameters, which are the precursor concentration, the nature of the functional groups or the nature of lipids on the surfaces. This allows the growth of isolated PB nanopyramids and nanocubes or the design of thin dense films over centimeter square surfaces. The formation of unusual Prussian blue nanopyramids is discussed. Finally, we demonstrate, by using experimental techniques and theoretical modeling, that PB nanoparticles deposited on the gold surface exhibit strong photothermal properties, permitting a rapid temperature increase up to 90 °C with a conversion of the laser power of almost 50% for power source heat.

SUBMITTER: Ngo G

PROVIDER: S-EPMC8308188 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Facile Synthesis of Novel Prussian Blue-Lipid Nanocomplexes.

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| S-EPMC6891449 | biostudies-literature

Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy.

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| S-EPMC6208784 | biostudies-literature

Bimodal Antimicrobial Surfaces of Phytic Acid-Prussian Blue Nanoparticles-Cationic Polymer Networks.

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| S-EPMC10238204 | biostudies-literature

Zinc-doped Prussian blue nanoparticles for mutp53-carrying tumor ion interference and photothermal therapy.

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Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis <i>via</i> Photothermal and Chemodynamic Therapy.

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Fluorescence imaging-guided cancer photothermal therapy using polydopamine and graphene quantum dot-capped Prussian blue nanocubes.

Project description:In recent years, imaging-guided photothermal tumor ablation has attracted intense research interest as one of the most exciting strategies for cancer treatment. Herein, we prepared polydopamine and graphene quantum dot-capped Prussian blue nanocubes (PB@PDA@GQDs, PBPGs) with high photothermal conversion efficiency and excellent fluorescence performance for imaging-guided cancer treatment. Transmission electron microscopy (TEM), UV-vis absorption spectroscopy (UV-vis), fluorescence spectroscopy, and X-ray photoelectron spectroscopy (XPS) were employed to characterize their morphology and structures. The photothermal conversion efficiency and therapeutic effect were evaluated in vitro and in vivo. Results revealed that this nanoagent had excellent biocompatibility and enhanced the photothermal effect compared to blue nanocubes (PBs) and polydopamine-capped Prussian blue nanocubes (PB@PDA, PBPs). Therefore, our study may open a new path for the production of PB-based nanocomposites as theranostic nanoagents for imaging-guided photothermal cancer treatment.

| S-EPMC8695181 | biostudies-literature

Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds.

Project description:The application of photothermal therapy to treat bacterial infections remains a challenge, as the high temperatures required for bacterial elimination can damage healthy tissues. Here, we develop an exogenous antibacterial agent consisting of zinc-doped Prussian blue (ZnPB) that kills methicillin-resistant Staphylococcus aureus in vitro and in a rat model of cutaneous wound infection. Local heat triggered by the photothermal effect accelerates the release and penetration of ions into the bacteria, resulting in alteration of intracellular metabolic pathways and bacterial killing without systemic toxicity. ZnPB treatment leads to the upregulation of genes involved in tissue remodeling, promotes collagen deposition and enhances wound repair. The efficient photothermal conversion of ZnPB allows the use of relatively few doses and low laser flux, making the platform a potential alternative to current antibiotic therapies against bacterial wound infections.

| S-EPMC6776522 | biostudies-literature

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Project description:Certain types of face masks are highly efficient in protecting humans from bacterial and viral pathogens, and growing concerns with high safety, low cost, and wide market suitability have accelerated the replacement of reusable face masks with disposable ones during the last decades. However, wearing these masks creates countless problems associated with personnel comfort as well as more significant issues related to the cost of fabrication, the generation of medical waste, and environmental contaminants. In this work, we present a facile spray-pressing technique for the production of P-masks with a potential scale-up prospect by adding a graphene layer on one side of meltblown fabric and a functional layer on the other side. In principle, this technique could be easily integrated into the present automatic mask production process and the masks have self-cleaning and/or self-sterilizing properties when it is exposed to solar or simulated solar irradiation.

| S-EPMC10374458 | biostudies-literature

Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects.

Project description:BackgroundPhotothermal therapy (PTT), involving application of localized hyperthermia to kill cancer cells, has attracted wide attention in cancer therapy. The production of reactive oxygen species (ROS) during PTT may cause irreversible damage to healthy tissues around the tumor. Simultaneously, hyperthermia can stimulate inflammatory response, thus promoting tumor recurrence and metastasis. Therefore, it is of paramount importance to reduce the undesired side effects for further development of PTT.ResultsUsing a hydrothermal method, spherical Prussian blue nanoparticles (PBs) with uniform size were prepared. The PBs exhibited good dispersion and stability in saline with an average hydrodynamic size of 110 nm. The prepared PBs had a high photothermal conversion efficiency and photothermal stability. The PBs showed intrinsic ROS scavenging properties in vitro. Antioxidant and anti-inflammatory effects of PBs were also observed in vivo. Assessment of toxicity and endoplasmic reticulum stress-inducing ability showed that PBs did not induce an inflammatory response. Tissues of major organs of mice stained with hematoxylin-eosin showed no significant damage, indicating good biocompatibility and safety of PBs.ConclusionThe designed single-component PBs with intrinsic ROS scavenging and anti-inflammatory properties could avoid inflammatory response and heat stress-induced ROS during PTT. Thus, further research on PBs is worthwhile to achieve their clinical translation and promote the development of PTT.

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| S-EPMC5074312 | biostudies-literature

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