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Targeting Viral Surface Proteins through Structure-Based Design.

ABSTRACT: The emergence of novel viral infections of zoonotic origin and mutations of existing human pathogenic viruses represent a serious concern for public health. It warrants the establishment of better interventions and protective therapies to combat the virus and prevent its spread. Surface glycoproteins catalyzing the fusion of viral particles and host cells have proven to be an excellent target for antivirals as well as vaccines. This review focuses on recent advances for computational structure-based design of antivirals and vaccines targeting viral fusion machinery to control seasonal and emerging respiratory viruses.

SUBMITTER: Narkhede YB

PROVIDER: S-EPMC8310314 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Targeting Viral Surface Proteins through Structure-Based Design.

Narkhede Yogesh B YB Gonzalez Karen J KJ Strauch Eva-Maria EM

Viruses 20210708 7

The emergence of novel viral infections of zoonotic origin and mutations of existing human pathogenic viruses represent a serious concern for public health. It warrants the establishment of better interventions and protective therapies to combat the virus and prevent its spread. Surface glycoproteins catalyzing the fusion of viral particles and host cells have proven to be an excellent target for antivirals as well as vaccines. This review focuses on recent advances for computational structure-b ...[more]

PMID: 34372526

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