Ontology highlight
ABSTRACT:
SUBMITTER: Saif M
PROVIDER: S-EPMC8310386 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Saif Mari M Kwanten Wilhelmus J WJ Carr Jessica A JA Chen Ivy X IX Posada Jessica M JM Srivastava Amitabh A Zhang Juanye J Zheng Yi Y Pinter Matthias M Chatterjee Sampurna S Softic Samir S Kahn C Ronald CR van Leyen Klaus K Bruns Oliver T OT Jain Rakesh K RK Bawendi Moungi G MG
Nature biomedical engineering 20200622 8
Monitoring the progression of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging methods. Here, we show that the endogenous pigment lipofuscin displays strong near-infrared and shortwave-infrared fluorescence when excited at 808 nm, enabling label-free imaging of liver injury in mice and the discrimination of pathological processes from normal liver processes with high specificity and sensitivity. We also show that the near-infrared and shortwave-infrared fl ...[more]