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Synthetic Carbohydrate Chemistry and Translational Medicine.

ABSTRACT: The importance of post-translational glycosylation in protein structure and function has gained significant clinical relevance recently. The latest developments in glycobiology, glycochemistry, and glycoproteomics have made the field more manageable and relevant to disease progression and immune-response signaling. Here, we summarize the current progress in glycoscience, including the new methodologies that have led to the introduction of programmable and automatic as well as large-scale enzymatic synthesis, and the development of glycan array, glycosylation probes, and inhibitors of carbohydrate-associated enzymes or receptors. These novel methodologies and tools have facilitated our understanding of the significance of glycosylation and development of carbohydrate-derived medicines that bring the field to the next level of scientific and medical significance.

SUBMITTER: Shivatare SS

PROVIDER: S-EPMC8312278 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Synthetic Carbohydrate Chemistry and Translational Medicine.

Shivatare Sachin S SS Wong Chi-Huey CH

The Journal of organic chemistry 20201030 24

The importance of post-translational glycosylation in protein structure and function has gained significant clinical relevance recently. The latest developments in glycobiology, glycochemistry, and glycoproteomics have made the field more manageable and relevant to disease progression and immune-response signaling. Here, we summarize the current progress in glycoscience, including the new methodologies that have led to the introduction of programmable and automatic as well as large-scale enzymat ...[more]

PMID: 33125238

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