Dataset Information

Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos.

ABSTRACT:

Introduction

We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults.

Methods

We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates.

Results

Longer sleep-onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep-onset latency was also cross-sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change.

Conclusion

In a cohort of mostly middle-aged Hispanic/Latinos, actigraphy-derived sleep-onset latency predicted 7-year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.

SUBMITTER: Agudelo C

PROVIDER: S-EPMC8312581 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Publications

Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos.

Agudelo Christian C Tarraf Wassim W Wu Benson B Wallace Douglas M DM Patel Sanjay R SR Redline Susan S Kaur Sonya S Daviglus Martha M Zee Phyllis C PC Simonelli Guido G Mossavar-Rahmani Yasmin Y Sotres-Alvarez Daniela D Zeng Donglin D Gallo Linda C LC González Hector M HM Ramos Alberto R AR

Alzheimer's & dementia : the journal of the Alzheimer's Association 20201222 6

<h4>Introduction</h4>We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults.<h4>Methods</h4>We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjust ...[more]

PMID: 33350583

Similar Datasets

Project description:ImportanceThe Mediterranean diet may reduce the burden of Alzheimer disease and other associated dementias in Hispanic or Latino people.ObjectiveTo investigate the association of a Mediterranean diet with cognitive performance among community-dwelling Hispanic or Latino adults.Design, setting, and participantsThis cohort study analyzed data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA), an HCHS/SOL ancillary study. Cognition tests were administered in the HCHS/SOL from March 2008 to June 2011 (visit 1) and in the SOL-INCA from October 2015 to March 2018 (visit 2). Participants included in the present study had completed a diet assessment at visit 1 and neurocognitive evaluations at visits 1 and 2. Data were analyzed from September 2021 to May 2022.ExposuresMediterranean diet adherence was ascertained using the Mediterranean diet score (MDS) and was categorized as low (MDS: 0-4 points), moderate (MDS: 5-6 points), or high (MDS: 7-9 points). The mean of two 24-hour dietary recalls was used to calculate the MDS.Main outcomes and measuresCognitive change between visits 1 and 2 was calculated by subtracting the cognitive score at visit 2 from the cognitive score at visit 1 and adjusting by the time elapsed between visits and cognitive score at visit 1. Neurocognitive tests administered were Brief Spanish-English Verbal Learning Test (B-SEVLT) Sum, B-SEVLT Recall, word fluency, and Digit Symbol Substitution Test (DSST). Results of each test were z score-transformed and the means were averaged to create a global cognition score. Complex sample linear regression analysis was used to ascertain the association between MDS and neurocognitive performance at each visit and neurocognitive change.ResultsA total of 6321 participants (mean [SE] age, 56.1 [0.18] years at visit 1; n = 4077 women [57.8%]) were included. Mediterranean diet adherence weighted frequencies were 35.8% (n = 2112 of 6321) for the low adherence group, 45.4% (n = 2795) for the moderate adherence group, and 18.8% (n = 1414) for the high adherence group. In the fully adjusted model, z score-transformed cognitive scores at visit 1 in the high vs low adherence groups were higher for B-SEVLT Sum (β = 0.11; 95% CI, 0.02-0.20), B-SEVLT Recall (β = 0.16; 95% CI, 0.07-0.25), and global cognition (β = 0.10; 95% CI, 0.04-0.16) tests. In the mean follow-up time of 7 years, cognitive change in the high vs low adherence groups was less pronounced for B-SEVLT Sum (β = 0.12; 95% CI, 0.05-0.20) and B-SEVLT Recall (β = 0.14; 95% CI, 0.05-0.23), but not for word fluency, DSST score, or global cognition score.Conclusions and relevanceResults of this cohort study suggested that high adherence to a Mediterranean diet was associated with better cognitive performance and decreased 7-year learning and memory decline among middle-aged and older Hispanic or Latino adults. Culturally tailored Mediterranean diet may reduce the risk of cognitive decline and Alzheimer disease in this population.

Dataset Information

Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos.

Introduction

Methods

Results

Conclusion

Publications

Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos.

Similar Datasets

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