White Matter Alterations Associated with Pro-inflammatory Cytokines in Patients with Major Depressive Disorder.

ABSTRACT:

Objective

Regarding the neuroinflammatory theory of major depressive disorder (MDD), little is known about the effect of pro-inflammatory cytokines on white matter (WM) changes in MDD. We aimed to investigate the relationship between pro-inflammatory cytokines and WM alterations in patients with MDD.

Methods

Twenty-two patients with MDD and 22 healthy controls (HC) were evaluated for brain imaging and pro-inflammatory cytokines including interleukin (IL)-1β, IL-6, IL-8, interferon-γ and tumor necrosis factor (TNF)-α. Tract-based spatial statistics and FreeSurfer were used for brain image analysis.

Results

The levels of TNF-α and IL-8 were significantly higher in the MDD group than in HC. Compared to HC, lower fractional anisotropy (FA), and higher median diffusivity (

SUBMITTER: Lim J 

PROVIDER: S-EPMC8316659 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature