Effects of perioperative rosuvastatin on postoperative delirium in elderly patients: A randomized, double-blind, and placebo-controlled trial.

ABSTRACT:

Background

Experimental evidence has indicated the benefits of statins for the treatment of postoperative delirium. Previously, clinical trials did not reach definite conclusions on the effects of statins on delirium. Some clinical trials have indicated that statins reduce postoperative delirium and improve outcomes, while some studies have reported negative results.

Aim

To evaluate whether perioperative rosuvastatin treatment reduces the incidence of delirium and improves clinical outcomes.

Methods

This randomized, double-blind, and placebo-controlled trial was conducted in a single center in Jiangsu, China. This study enrolled patients aged greater than 60 years who received general anesthesia during elective operations and provided informed consent. A computer-gene

SUBMITTER: Xu XQ 

PROVIDER: S-EPMC8316934 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature