Ontology highlight
ABSTRACT:
SUBMITTER: Ker DS
PROVIDER: S-EPMC8318291 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Ker De-Sheng DS Jenkins Huw T HT Greive Sandra J SJ Antson Alfred A AA
PLoS pathogens 20210716 7
Nipah and its close relative Hendra are highly pathogenic zoonotic viruses, storing their ssRNA genome in a helical nucleocapsid assembly formed by the N protein, a major viral immunogen. Here, we report the first cryoEM structure for a Henipavirus RNA-bound nucleocapsid assembly, at 3.5 Å resolution. The helical assembly is stabilised by previously undefined N- and C-terminal segments, contributing to subunit-subunit interactions. RNA is wrapped around the nucleocapsid protein assembly with a p ...[more]