Innate Immune Cytokine Profiling and Biomarker Identification for Outcome in Dengue Patients.

ABSTRACT:

Background

Early biomarkers of progression to severe dengue are urgently required to enable effective patient management and control treatment costs. Innate immune cells, which comprise the earliest responders to infection and along with the cytokines and chemokines they secrete, play a vital role in orchestrating the subsequent adaptive immune response and have been implicated in the enhancement of infection and "cytokine storm" associated with dengue severity. We investigated the early innate immune cytokine profile of dengue patients during acute phase of disease in a prospective blinded study that included subjects with acute dengue and febrile controls from four major hospitals in Bengaluru, India along with healthy controls. We used intracellular cytokine staining and flow cy

SUBMITTER: Pradeep SP 

PROVIDER: S-EPMC8318829 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature