Ontology highlight
ABSTRACT:
SUBMITTER: Hemaida AY
PROVIDER: S-EPMC8320107 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Hemaida Aya Y AY Hassan Ghada S GS Maarouf Azza R AR Joubert Jacques J El-Emam Ali A AA
ACS omega 20210719 29
Nineteen new thiazole-based derivatives were synthesized and their structures characterized with analytical and spectral data. The <i>in vitro</i> assessment of their acetylcholinesterase (AChE) inhibitory activity revealed that compounds <b>10</b> and <b>16</b> produced potent AChE inhibitory activities with IC<sub>50</sub> values of 103.24 and 108.94 nM, respectively. Compounds <b>13</b>, <b>17</b>, <b>18</b>, <b>21</b>, <b>23</b>, <b>31</b>, and <b>33</b> displayed moderate activity with 25-5 ...[more]