Association of endothelial nitric oxide synthase gene variants with preeclampsia.

ABSTRACT:

Background

Preeclampsia (PE) is a complex pregnancy hypertensive disorder with multifaceted etiology. The endothelial nitric oxide synthase (eNOS) gene and nitric oxide (NO) levels has been reported to be associated with PE predisposition in various populations. Therefore, present study was designed to investigate the role of NO levels and eNOS gene variants in preeclamptic women in Pakistan.

Methods

A total of 600 women were evaluated, 188 of PE with mild features, 112 of PE with severe features and 300 normotensive pregnant women. NO levels were detected by Greiss reaction method and genotyping following sequencing was conducted for eNOS gene variants. Further insilico studies were performed to get insights into the structural and functional impact of identifies mutation o

SUBMITTER: Shaheen G 

PROVIDER: S-EPMC8320179 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature