RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling.
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ABSTRACT: We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and controlled toward Darwinian evolution in RNA reaction networks.
SUBMITTER: Jeancolas C
PROVIDER: S-EPMC8320737 | biostudies-literature |
REPOSITORIES: biostudies-literature
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