Ontology highlight
ABSTRACT:
SUBMITTER: Ghouil R
PROVIDER: S-EPMC8322138 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Ghouil Rania R Miron Simona S Koornneef Lieke L Veerman Jasper J Paul Maarten W MW Le Du Marie-Hélène MH Sleddens-Linkels Esther E van Rossum-Fikkert Sari E SE van Loon Yvette Y Felipe-Medina Natalia N Pendas Alberto M AM Maas Alex A Essers Jeroen J Legrand Pierre P Baarends Willy M WM Kanaar Roland R Zinn-Justin Sophie S Zelensky Alex N AN
Nature communications 20210729 1
BRCA2 and its interactors are required for meiotic homologous recombination (HR) and fertility. Loss of HSF2BP, a BRCA2 interactor, disrupts HR during spermatogenesis. We test the model postulating that HSF2BP localizes BRCA2 to meiotic HR sites, by solving the crystal structure of the BRCA2 fragment in complex with dimeric armadillo domain (ARM) of HSF2BP and disrupting this interaction in a mouse model. This reveals a repeated 23 amino acid motif in BRCA2, each binding the same conserved surfa ...[more]