A tool for analyzing and visualizing ribo-seq data at the isoform level.

ABSTRACT:

Background

Translational regulation is one important aspect of gene expression regulation. Dysregulation of translation results in abnormal cell physiology and leads to diseases. Ribosome profiling (RP), also called ribo-seq, is a powerful experimental technique to study translational regulation. It can capture a snapshot of translation by deep sequencing of ribosome-protected mRNA fragments. Many ribosome profiling data processing tools have been developed. However, almost all tools analyze ribosome profiling data at the gene level. Since different isoforms of a gene may produce different proteins with distinct biological functions, it is advantageous to analyze ribosome profiling data at the isoform level. To meet this need, previously we developed a pipeline to analyze 610 publi

SUBMITTER: Wu WS 

PROVIDER: S-EPMC8323483 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature