Proteomic analysis reveals some common proteins in the kidney stone matrix.

ABSTRACT:

Background

Proteins are the most abundant component of kidney stone matrices and their presence may reflect the process of the stone's formation. Many studies have explored the proteomics of urinary stones and crystals. We sought to comprehensively identify the proteins found in kidney stones and to identify new, reliable biomolecules for use in nephrolithiasis research.

Methods

We conducted bioinformatics research in November 2020 on the proteomics of urinary stones and crystals. We used the ClusterProfiler R package to transform proteins into their corresponding genes and Ensembl IDs. In each study we located where proteomic results intersected to determine the 20 most frequently identified stone matrix proteins. We used the Human Protein Atlas to obtain the biological inf

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8323604 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature