System Modularity Chip for Analysis of Rare Targets (SMART-Chip): Liquid Biopsy Samples.

ABSTRACT: Liquid biopsies are becoming popular for managing a variety of diseases due to the minimally invasive nature of their acquisition, thus potentially providing better outcomes for patients. Circulating tumor cells (CTCs) are among the many different biomarkers secured from a liquid biopsy, and a number of efficient platforms for their isolation and enrichment from blood have been reported. However, many of these platforms require manual sample handling, which can generate difficulties when translating CTC assays into the clinic due to potential sample loss, contamination, and the need for highly specialized operators. We report a system modularity chip for the analysis of rare targets (SMART-Chip) composed of three task-specific modules that can fully automate processing of CTCs. The modules

SUBMITTER: Pahattuge TN 

PROVIDER: S-EPMC8325110 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature