Genetic alterations and functional networks of m6A RNA methylation regulators in pancreatic cancer based on data mining.

ABSTRACT:

Background

Pancreatic cancer is a fatal malignancy of the digestive system and the 5-year survival rate remains low. Therefore, new molecular therapeutic targets are required to improve treatments, prognosis, and the survival of patients. N6-methyladenosine (m6A) is the most prevalent reversible methylation in mammalian messenger RNA (mRNA) and has critical roles in the tumorigenesis and metastasis of various malignancies. However, the role of m6A in pancreatic cancer is still unclear. Exploring genetic alterations and functional networks of m6A regulators in pancreatic cancer may provide new strategies for its treatment.

Methods

In this study, we used data from the Cancer Genome Atlas (TCGA) database and other public databases through cBioPortal, LinkedOmics, UALCAN, GEPIA,

SUBMITTER: Zeng J 

PROVIDER: S-EPMC8325265 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature