One-year aerobic exercise altered cerebral vasomotor reactivity in mild cognitive impairment.

ABSTRACT: The purpose of this study was to test the hypothesis that changes in cerebral vasomotor reactivity (CVMR) after 1-yr aerobic exercise training (AET) are associated with cognitive performances in individuals with amnestic mild cognitive impairment (MCI). Seventy sedentary patients with amnestic MCI were randomized to 1-yr moderate-to-vigorous intensity AET or stretching and toning (SAT) interventions. Cerebral blood flow velocity (CBFV) with transcranial Doppler, mean arterial pressure (MAP) with finapres plethysmograph, and EtCO₂ with capnography were measured during hyperventilation (hypocapnia) and a modified rebreathing protocol (hypercapnia) to assess CVMR. Cerebrovascular conductance index (CVCi) was calculated by CBFV/MAP, and CVMR by ΔCBFV/ΔEtCO₂ and ΔCVCi/ΔEtC

SUBMITTER: Tomoto T 

PROVIDER: S-EPMC8325610 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature