Ontology highlight
ABSTRACT:
SUBMITTER: Jang JK
PROVIDER: S-EPMC8325958 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Jang Janet K JK Gladstein Amy C AC Das Arunika A Shapiro Joanatta G JG Sisco Zachary L ZL McKim Kim S KS
Journal of cell science 20210723 14
Meiosis in female oocytes lacks centrosomes, the microtubule-organizing centers. In Drosophila oocytes, meiotic spindle assembly depends on the chromosomal passenger complex (CPC). To investigate the mechanisms that regulate Aurora B activity, we examined the role of protein phosphatase 2A (PP2A) in Drosophila oocyte meiosis. We found that both forms of PP2A, B55 and B56, antagonize the Aurora B spindle assembly function, suggesting that a balance between Aurora B and PP2A activity maintains the ...[more]