Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC8326117 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Chen Jiang J Li Song S Lei Zhifeng Z Tang Qinmin Q Mo Ling L Zhao Xing X Xie Feifei F Zi Dan D Tan Jun J
International journal of biological sciences 20210713 11
SARS-CoV-2 invades host cells mainly through the interaction of its spike-protein with host cell membrane ACE2. Various antibodies targeting S-protein have been developed to combat COVID-19 pandemic; however, the potential risk of antibody-dependent enhancement and novel spike mutants-induced neutralization loss or antibody resistance still remain. Alternative preventative agents or therapeutics are still urgently needed. In this study, we designed series of peptides with either ACE2 protecting ...[more]