Ontology highlight
ABSTRACT:
SUBMITTER: Kessler T
PROVIDER: S-EPMC8326228 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Kessler Thorsten T Schunkert Heribert H
JACC. Basic to translational science 20210726 7
Many cardiovascular diseases are facilitated by strong inheritance. For example, large-scale genetic studies identified hundreds of genomic loci that affect the risk of coronary artery disease. At each of these loci, common variants are associated with disease risk with robust statistical evidence but individually small effect sizes. Only a minority of candidate genes found at these loci are involved in the pathophysiology of traditional risk factors, but experimental research is making progress ...[more]