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Taurisolo®, a Grape Pomace Polyphenol Nutraceutical Reducing the Levels of Serum Biomarkers Associated With Atherosclerosis.

ABSTRACT: Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite recognized as strongly related to cardiovascular diseases (CVD), mainly increasing the risk of atherosclerosis development. Currently, no pharmacological approaches have been licensed for reduction of TMAO serum levels and conventional anti-atherosclerosis treatments only target the traditional risk factors, and the cardiovascular risk (CVR) still persist. This underlines the need to find novel targeted strategies for management of atherosclerosis. In this study we tested the ability of a novel nutraceutical formulation based on grape pomace polyphenols (Taurisolo®) in reducing both the serum levels of TMAO and oxidative stress-related biomarkers in humans (n = 213). After chronic treatment with Taurisolo® we observed significantly reduced levels of TMAO (-49.78 and -75.80%, after 4-week and 8-week treatment, respectively), oxidized LDL (oxLDL; -43.12 and -65.05%, after 4-week and 8-week treatment, respectively), and reactive oxygen species (D-ROMs; -34.37 and -49.68%, after 4-week and 8-week treatment, respectively). On the other hand, no significant changes were observed in control group. Such promising, the results observed allow indicating Taurisolo® as an effective nutraceutical strategy for prevention of atherosclerosis. Clinical Trial Registration: This study is listed on the ISRCTN registry with ID ISRCTN10794277 (doi: 10.1186/ISRCTN10794277).

SUBMITTER: Annunziata G

PROVIDER: S-EPMC8326362 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:This study presents a new type of biomass material for defluoridation from water; the material was prepared by loading tetravalent zirconium ions onto grape pomace produced from grape juicing and wine factories. Experiments showed that the optimum pH of defluoridation is around 3.0, and the fluorine removal efficiency could reach 96.13% for one-time contact. In batchwise adsorption tests, it was very interesting to find that even at pH values near 10, at which traditional adsorbents usually do not function for defluoridation, the removal efficiency of fluoride was still more than 90% for the Zr(iv)-loaded grape pomace (Zr(iv)-GP) biosorbent; proton release from Zr(iv)-GP was confirmed to cause an automatic decrease of the pH, which can save additional acid consumption in the case of one-time use and render the defluoridation more convenient and efficient. The maximum adsorption capacity of Zr(iv)-GP was 7.54 mg g-1; as a comparison, the maximum adsorption capacities of zirconium-loaded strongly acidic ion exchange resin D001 and zirconium-loaded weakly acidic ion exchange resin D113 were evaluated to be 4.85 mg g-1 and 1.14 mg g-1, respectively. The effects of coexisting anions, such as Cl-, NO3-, SO4 2-, CO3 2- and HPO4 2-, on the fluorine removal efficiency were also examined; it was found that CO3 2- and HPO4 2- anions had drastically adverse effects on defluoridation, while Cl-, NO3-, and SO4 2- appeared not to interfere. Real groundwater containing 1.8 mg L-1 fluoride sampled from Guanzhuang Village in Haixing County of Hebei Province was used for defluoridation through a continuous column adsorption process; it was found that pre-adjusting the groundwater pH affected the purification efficiency drastically, i.e., the time of the breakthrough point for the inlet groundwater pH at 3.0 was about 8 times longer than that at the original pH of 8.18. In addition, the Zr(iv)-GP adsorbent retained good adsorption capacity even after 3 cycles of adsorption-desorption-adsorption operations, indicating that the synthesized zirconium-loaded grape pomace is a very promising new fluorine-removing material for groundwater purification.

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Taurisolo®, a Grape Pomace Polyphenol Nutraceutical Reducing the Levels of Serum Biomarkers Associated With Atherosclerosis.

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