Ontology highlight
ABSTRACT:
SUBMITTER: Hilal S
PROVIDER: S-EPMC8327109 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Hilal Saima S Liu Siwei S Wong Tien Yin TY Vrooman Henri H Cheng Ching-Yu CY Venketasubramanian Narayanaswamy N Chen Christopher Lh CL Zhou Juan Helen JH
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20210202 8
To determine whether white matter network disruption mediates the association between MRI markers of cerebrovascular disease (CeVD) and cognitive impairment. Participants (n = 253, aged ≥60 years) from the Epidemiology of Dementia in Singapore study underwent neuropsychological assessments and MRI. CeVD markers were defined as lacunes, white matter hyperintensities (WMH), microbleeds, cortical microinfarcts, cortical infarcts and intracranial stenosis (ICS). White matter microstructure damage wa ...[more]