Ontology highlight
ABSTRACT:
SUBMITTER: Molenaar MR
PROVIDER: S-EPMC8327380 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Molenaar Martijn R MR Yadav Kamlesh K KK Toulmay Alexandre A Wassenaar Tsjerk A TA Mari Muriel C MC Caillon Lucie L Chorlay Aymeric A Lukmantara Ivan E IE Haaker Maya W MW Wubbolts Richard W RW Houweling Martin M Vaandrager Arie Bas AB Prieur Xavier X Reggiori Fulvio F Choudhary Vineet V Yang Hongyuan H Schneiter Roger R Thiam Abdou Rachid AR Prinz William A WA Helms J Bernd JB
The Journal of cell biology 20210729 10
Lipid droplets store neutral lipids, primarily triacylglycerol and steryl esters. Seipin plays a role in lipid droplet biogenesis and is thought to determine the site of lipid droplet biogenesis and the size of newly formed lipid droplets. Here we show a seipin-independent pathway of lipid droplet biogenesis. In silico and in vitro experiments reveal that retinyl esters have the intrinsic propensity to sequester and nucleate in lipid bilayers. Production of retinyl esters in mammalian and yeast ...[more]