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Longitudinal naming and repetition relates to AD pathology and burden in autopsy-confirmed primary progressive aphasia.


ABSTRACT:

Introduction

In primary progressive aphasia (PPA) patients with autopsy-confirmed Alzheimer's disease (AD) or frontotemporal lobar degeneration (FLTD), we tested how the core clinical features of logopenic PPA-naming and repetition-change over time and relate to pathologic burden.

Methods

In PPA with AD (n = 13) or FTLD (n = 16) pathology, Boston Naming Test and Forward Digit Span measured longitudinal naming and repetition; as reference, Mini-Mental State Examination (MMSE) measured global cognition. Pathologic burden in left peri-Sylvian regions was related to longitudinal cognitive decline.

Results

PPA with AD showed greater decline in naming (= 0.021) and repetition (= 0.020), compared to FTLD; there was no difference in MMSE decline (= 0.99). Across all PPA, declining naming (= 0.0084) and repetition (= 0.011) were associated with angular, superior-middle temporal (naming = 0.014; repetition = 0.011) and middle frontal (naming = 0.041; repetition = 0.030) pathologic burden.

Discussion

Unique longitudinal profiles of naming and repetition performance in PPA with AD are related to left peri-Sylvian pathology.

SUBMITTER: Cousins KAQ 

PROVIDER: S-EPMC8327471 | biostudies-literature |

REPOSITORIES: biostudies-literature

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